Replication and compartmentalization of Dobrava-Belgrade virus in the central nervous system
A heart-transplant recipient developed fatal neurologic disease. High-throughput sequencing (HTS) identified Dobrava - Belgrade virus in central nervous system (CNS) and peripheral specimens. Genomic analyzes showed distinct viral populations across compartments, suggesting CNS tropism. This case highlights atypical infection presentations in immunosuppressed patients and underscores the diagnostic value of HTS.
Authors
- Till D. Best
- Julia Melchert (ORCID: https://orcid.org/0000-0002-0494-1022)
- Helena Radbruch (ORCID: https://orcid.org/0000-0001-6941-3397)
- Jenny Meinhardt (ORCID: https://orcid.org/0000-0003-0366-2416)
- Eberhard Siebert (ORCID: https://orcid.org/0000-0001-7395-6546)
- Marie Luisa Schmidt (ORCID: https://orcid.org/0000-0002-8512-7531)
- Jörg Hofmann (ORCID: https://orcid.org/0000-0003-3966-515X)
- Farid Salih (ORCID: https://orcid.org/0000-0003-1114-3181)
- Talitha Veith (ORCID: https://orcid.org/0000-0002-0484-6332)
- Lisa Müller
- Victor Max Corman
- Jörn Beheim-Schwarzbach
- Felix Schoenrath
- Christian Drosten
- Julia Herzig-Nichtweiss
- Terry C. Jones
Institutions
- Humboldt-Universität zu Berlin (DE)
- Deutsches Herzzentrum der Charité (DE)
- Evolutionary Genomics (United States) (US)
- Vivantes Klinikum (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Emerging Microbes & Infections
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1080/22221751.2026.2673649
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Infektionsforschung
- National University of Mongolia
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Bildung und Frauen