Discovery of Imidazo[1, 2- <i>a</i> ]pyridine Hydrazone Derivatives as Novel Antifungal Tubulin-Targeting Agents via a Scaffold-Hopping Strategy
formed multiple hydrogen bonds and π-π interactions with tubulin, and further induced intracellular microtubule aggregation, thereby disrupting both hyphal morphology and cellular architecture. This study provides strong evidence for structural diversification in tubulin-targeting antifungal agents, offering new perspectives for overcoming existing limitations in antifungal therapy.
Authors
- Zhou‐Qing Long
- Xian-Qun Hu
- Long‐Fei Li
- L Y Zhang
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-3589-9074)
- Hong‐Wu Liu
- Zhenhua Li (ORCID: https://orcid.org/0000-0001-8087-0687)
- Yuanyuan Wu (ORCID: https://orcid.org/0000-0003-4783-5366)
- Yu Long
- Xin-Ming Yang
- Mei Li
- Song Yang (ORCID: https://orcid.org/0000-0003-1301-3030)
Institutions
- Bureau of Plant Industry (PH)
- Guizhou University (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1021/acs.jafc.5c12629
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China