Discovery of Selective Inhibitors for β-Actin Polymerization as Potential Anticancer Agents <i>In Vitro</i> and <i>In Vivo</i>
represents the first selective inhibitor of β-actin. This provides valuable insights and a foundation for subsequent research on the selectivity of actins and related drug discovery.
Authors
- Weixiong Chen (ORCID: https://orcid.org/0000-0002-1385-2654)
- Shunying Liu (ORCID: https://orcid.org/0000-0002-3894-757X)
- Jinhua Liu (ORCID: https://orcid.org/0000-0002-4031-3031)
- Donghui Sun
- Zongjing Hu
- Jiarui Chang
- Meng Li
- Tong Zhu (ORCID: https://orcid.org/0000-0001-7472-3736)
- Shilong Hao
- Ya Gao
- Yikai Xu
Institutions
- Chongqing Normal University (CN)
- Shanghai University of Engineering Science (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00299
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- National Key Research and Development Program of China