Antidermatophytic Activity of Curcuma longa and Zingiber officinale Essential Oils

novel, biogenic therapeutic alternatives. 10Previous reports show that Curcuma longa can be used for superficial skin diseases.Essential oils and rhizomes have great importance. 11Essential oils are also extracted from C. longa leaves, which show antifungal, antioxidant, and antidiabetic activity that was validated by further clinical trials.Various studies are available on the antimicrobial property and chemical composition of fresh ginger oil and other naturally occurring compounds. [12][13]3][14][15] Various reports are available on the rhizomes of ginger. 16,17Essential oils serve as concentrated reservoirs of biologically active secondary metabolites, which demonstrate potent and broad- IntroductIonSuperficial mycoses represent a major global health challenge, affecting 20-25% of the world's population, with over one billion cases documented as of 2010. 1 Previous studies have reported that cutaneous fungal infections account for over 29.4 million cases and >51 million physician visits annually in the United States.These infections are primarily caused by a specialized group of fungi known as dermatophytes.By colonizing keratinized tissues-including the skin, hair, and nails-these pathogens, which belong to the genera Trichophyton, Microsporum, and Epidermophyton, remain a significant clinical challenge. 2-5Some fungal infections are difficult to treat with conventional antifungal drugs due to increasing resistance to conventional antifungal therapies.It was reported from previous studies that >20-50% of human skin infections caused by dermatophytes were from zoonotic sources. 6These zoonotic infections are easily transmitted from animals to humans. 7Previous studies reported the prevalence of >50-70% of human infections come from animal hosts or mainly pet animals. 8Several factors contribute to the prevalence of zoonotic fungal infections, including substandard hygienic conditions and inadequate management of domestic pets.Such environments facilitate the transmission of pathogens from infected animals to other livestock and humans, creating a persistent cycle of infection within the community, and penetrate the outermost layer of the epidermis regardless of a person's age. 9In recent years, the indiscriminate use of commercial antimicrobial agents has led to the emergence of multidrug-resistant (MDR) strains among infectious pathogens.This growing resistance profile complicates standard treatment protocols and underscores the urgent need for 1,