RGD-Functionalized ZIF-8 Nanocarriers Enable Highly Selective Delivery of Repurposed Gliclazide in Breast Cancer
) while maintaining reduced toxicity toward MRC-5 normal fibroblasts, resulting in a markedly improved selectivity index. Overall, this work demonstrates that RGD-functionalized nZIF-8 is a promising pH-responsive and selective nanoplatform for the targeted delivery of repurposed therapeutics in breast cancer treatment.
Authors
- Rosniza Razali
- Nurul Akmarina Mohd Abdul Kamal (ORCID: https://orcid.org/0000-0003-2927-4438)
- Mostafa Yousefzadeh Borzehandani (ORCID: https://orcid.org/0000-0002-9004-3308)
- Siti Hajar Noor Shaarani
- N. A. Johari (ORCID: https://orcid.org/0009-0003-7605-7441)
- Norazalina Saad (ORCID: https://orcid.org/0000-0003-1732-4645)
- Gaayatri Silvaraju
Institutions
- Universiti Malaysia Pahang Al-Sultan Abdullah (MY)
- Universiti Putra Malaysia (MY)
- Malaysian Nuclear Agency (MY)
- Shantou University (CN)
- Applied Medical Technology (United States) (US)
- Institute of Cancer Research (CA)
- Institute of Chemistry and Chemical Technology (MN)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1021/acsabm.6c00092
- Primary Topic
- Metal-Organic Frameworks: Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Higher Education, Malaysia