RATIONAL DESIGN OF PYRIMIDINE DERIVATIVES AS ANTICANCER AGENT

Pyrimidine is a six membered aromatic heterocyclic compound containing two nitrogen atom at position 1 & 3. Pyrimidine derivative has been used in drugs for various diseases. in this ,we use insilico drug design techniques to determine pharmacokinetics properties and binding affinity of 2 amino[1,3] thiazolo [4,5-d] pyrimidine5,7 [4h,6h]-dione and 4,6dimethy l-2 phenyl [1,3] oxozolo [4,5-d] pyrimidine-5,6 [4h,6h]-dione. The molecular structure were drawn using chemsketch, followed by prediction of pharmacokinetics properties by swiss ADME. The binding affinity was by using the docking software PyRx. Among this the compound 4, 6-dimethyl 2-phenyl [1,3] oxazolo [4,5-d] pyrimidine -5,7 [4h,6h]-dione has better anti-cancer activity based on binding affinity.