Identification of <i>Streptococcus pyogenes</i> isolates with reduced beta-lactam susceptibility in a cohort of children with pharyngitis
ABSTRACT We investigated sequences of the penicillin-binding protein 2x (PBP2x) among 902 Streptococcus pyogenes isolates from children with pharyngitis. Twenty-five pharyngeal isolates carried variants associated with reduced β-lactam susceptibility. Penicillin and ampicillin susceptibility testing confirmed reduced susceptibility among PBP2x variant isolates relative to those with the wild-type sequence.
Authors
- Ami B. Patel (ORCID: https://orcid.org/0000-0002-0626-4248)
- Preeti Jaggi (ORCID: https://orcid.org/0000-0003-0416-5171)
- Alan R. Hauser (ORCID: https://orcid.org/0000-0003-4596-7939)
- Robert R. Tanz (ORCID: https://orcid.org/0000-0002-1537-2873)
- Larry K. Kociolek (ORCID: https://orcid.org/0000-0002-8756-3417)
- Sophia Nozick (ORCID: https://orcid.org/0000-0002-0791-6340)
- Judith A. Guzman‐Cottrill (ORCID: https://orcid.org/0000-0002-3792-4405)
- Samuel W. M. Gatesy
- Stanford T. Shulman
- Egon A. Ozer
- Yiannis Katsogridakis (ORCID: https://orcid.org/0000-0002-7234-7164)
- Daniel B. Amusin (ORCID: https://orcid.org/0000-0001-8525-7566)
- Jennifer Sheridan (ORCID: https://orcid.org/0000-0003-2630-4152)
- Lacy M. Simons (ORCID: https://orcid.org/0000-0003-4041-6775)
- Dulce S. Garcia
- Rachel J. Tanz
- Emma Office (ORCID: https://orcid.org/0000-0003-2314-5213)
- David B. Williams
Institutions
- Lurie Children's Hospital (US)
- Emory University (US)
- Desert Valley Hospital (US)
- Lurie Children's Hospital (US)
- Doernbecher Children's Hospital (US)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1128/aac.00354-26
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Centers for Disease Control and Prevention