Heavy water labeling reveals metabolic flexibility of amino acid and polyamine pathways in mammalian cells
O and demonstrate that D₂O provides a sensitive readout of metabolic flexibility, transport crosstalk, and pathway regulation across cell types and tissues.
Authors
- Dawid Krokowski
- Maria Hatzoglou (ORCID: https://orcid.org/0000-0003-2037-1231)
- Piotr Właź (ORCID: https://orcid.org/0000-0002-5389-0241)
- Tomasz Sawoszczuk (ORCID: https://orcid.org/0000-0002-5479-1704)
- Katarzyna Socała (ORCID: https://orcid.org/0000-0001-7706-2080)
- Marek Tchórzewski (ORCID: https://orcid.org/0000-0002-0718-4223)
- Julio César Torres Elguera (ORCID: https://orcid.org/0000-0001-6598-5304)
- Nikola Gapińska (ORCID: https://orcid.org/0000-0001-6784-2032)
- Alan Gonzalez-Ibarra (ORCID: https://orcid.org/0000-0003-3740-5055)
- Wioleta Banaszuk-Krupa
- Missael Arroyo-Negrete (ORCID: https://orcid.org/0000-0002-1323-5453)
Institutions
- Maria Curie-Skłodowska University (PL)
- Krakow University of Economics (PL)
- AM Technologies (Poland) (PL)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Communications Chemistry
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1038/s42004-026-02081-9
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowe Centrum Nauki
- National Institutes of Health