Novel coumarin-1,2,3-triazole-isatin hybrids: design, synthesis, <i>in-vitro</i> , <i>in-silico</i> and SAR study for antimicrobial activity and α-glucosidase inhibition
AIM: ) and evaluate their dual biological potential as antimicrobials and α-Glucosidase Inhibitors. MATERIALS AND METHODS: (PDB ID: 1IYL), and (PDB ID: 3AJ7) were performed using molecular docking, MD simulation, and DFT methods. RESULTS AND DISCUSSION: findings by confirming the stability of protein-ligand complexes.
Authors
- Leena Khanna (ORCID: https://orcid.org/0000-0001-7438-8245)
- Pratibha Chanana
- Pankaj Khanna (ORCID: https://orcid.org/0000-0002-5282-7216)
- Shilpa Yadav
- Charu Bhutani
- Priyanshu
- Mansi (ORCID: https://orcid.org/0000-0002-3121-4242)
Institutions
- Guru Gobind Singh Indraprastha University (IN)
- University of Delhi (IN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1080/17568919.2026.2676786
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00