Irisin promotes selective changes in hippocampal mitochondrial metabolism in mice

Irisin, an exercise-induced hormone, exerts neuroprotective actions in neurological disease models, yet its effects on brain mitochondrial metabolism remain unclear. Here, we examined how irisin influences mitochondrial function and dynamics in the mouse hippocampus. Acute irisin exposure boosted ATP-coupled oxygen consumption without altering mitochondrial content or dynamics-related proteins. Furthermore, chronic irisin administration in vivo decreased hippocampal Opa1 and Drp1 levels, two key regulators of mitochondrial remodeling. These findings uncover selective actions of irisin on hippocampal mitochondrial homeostasis and identify prolonged irisin exposure as a potential regulator of mitochondrial dynamics in the brain.

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Publication Details

Journal
Biochemistry and Biophysics Reports
Published
2026-05-29
DOI
https://doi.org/10.1016/j.bbrep.2026.102657
Primary Topic
Adipose Tissue and Metabolism
Type
article
Field-Weighted Citation Impact
0.00

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article

Irisin promotes selective changes in hippocampal mitochondrial metabolism in mice

Andréa Tosta, Tiago Ferreira Lima, Mychael V. Lourenco, Sérgio T. Ferreira et al.
Biochemistry and Biophysics Reports
Adipose Tissue and Metabolism
article

Irisin promotes selective changes in hippocampal mitochondrial metabolism in mice

Andréa Tosta, Tiago Ferreira Lima, Mychael V. Lourenco, Sérgio T. Ferreira, Juliana Camacho-Pereira, Guilherme B. de Freitas, Mariana G. Chauvet, Felipe C. Ribeiro, Marcos A. Formiga-Jr, Fernanda G. De Felice, Marina S. Chichierchio, Ariene S. Fonseca
article en

Abstract

Irisin, an exercise-induced hormone, exerts neuroprotective actions in neurological disease models, yet its effects on brain mitochondrial metabolism remain unclear. Here, we examined how irisin influences mitochondrial function and dynamics in the mouse hippocampus. Acute irisin exposure boosted ATP-coupled oxygen consumption without altering mitochondrial content or dynamics-related proteins. Furthermore, chronic irisin administration in vivo decreased hippocampal Opa1 and Drp1 levels, two key regulators of mitochondrial remodeling. These findings uncover selective actions of irisin on hippocampal mitochondrial homeostasis and identify prolonged irisin exposure as a potential regulator of mitochondrial dynamics in the brain.

Biochemistry and Biophysics ReportsVol. 46
Universidade Federal do Rio de Janeiro (BR), Universidade Estadual de Campinas (UNICAMP) (BR), Queen's University (CA), D’Or Institute for Research and Education (BR), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
Alzheimer's Association, Instituto Nacional de Ciência e Tecnologia – Frutas Tropicais, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional, Instituto Serrapilheira
Good health and well-being
Openalex Percentile: Top 6%
Adipose Tissue and Metabolism
DOIOpen Access PDFOpenAlex
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