PFAS exposure modulates mitochondrial susceptibility in steatotic hepatocytes
• PFAS and steatosis jointly exacerbate mitochondrial metabolic dysfunction. • Steatosis enhances the PFAS-induced cardiolipin remodeling. • The PFAS-steatosis axis may promote mitochondrial lipid droplet accumulation. • Steatotic hepatocytes show heightened mitochondrial vulnerability to PFAS.
Authors
- Andi Alijagić (ORCID: https://orcid.org/0000-0002-2403-7989)
- Victor Castro-Alves
- João Marcos G. Barbosa
- Tuulia Hyötyläinen (ORCID: https://orcid.org/0000-0002-1389-8302)
- Lorane Valgueblasse
- Anh Hoang Nguyen
- Matej Orešič (ORCID: https://orcid.org/0000-0002-2856-9165)
Institutions
- Åbo Akademi University (FI)
- University of Turku (FI)
- Turku Centre for Computer Science (FI)
- Örebro University (SE)
- École Nationale Supérieure de Chimie de Rennes (FR)
Publication Details
- Journal
- Environment International
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1016/j.envint.2026.110337
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Skogs- och Jordbrukets Forskningsråd
- Stiftelsen för Kunskaps- och Kompetensutveckling
- Novo Nordisk Fonden
- HORIZON EUROPE Framework Programme