Sleep disturbances and respiratory dysfunction in amyotrophic lateral sclerosis

OBJECTIVE: To investigate how respiratory dysfunction and site of onset influences changes in sleep architecture in people with ALS (pwALS). METHODS: We conducted a retrospective observational study, analyzing demographic data, lung function tests, and polysomnography (PSG) measures. Descriptive statistics, correlation analyses, and survival analyses were performed. RESULTS: = 0.0059). Spinal onset, a slower rate of FVC decline in the months preceding PSG and a preserved FVC (≥ 70%) at the time of PSG were associated with improved survival. CONCLUSION: We observed substantial sleep disturbances in our cohort overall with substantially increased arousals in the spinal group. FVC is a significant predictor for sleep efficiency and the decline in FVC is linked to survival.

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Publication Details

Journal
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Published
2026-05-29
DOI
https://doi.org/10.1080/21678421.2026.2671162
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Sleep disturbances and respiratory dysfunction in amyotrophic lateral sclerosis

Alexandros Kalkanis, Dries Testelmans, Fouke Ombelet, Laura Van den Bulcke et al.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Amyotrophic Lateral Sclerosis Research
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Sleep disturbances and respiratory dysfunction in amyotrophic lateral sclerosis

Alexandros Kalkanis, Dries Testelmans, Fouke Ombelet, Laura Van den Bulcke, Bart Vrijsen, Anne-Marie Peeters, Boris Deleu, Kato Bracaval, Bertien Buyse, Joke De Vocht, Philip Van Damme, Maarten Van Den Bossche
article en

Abstract

OBJECTIVE: To investigate how respiratory dysfunction and site of onset influences changes in sleep architecture in people with ALS (pwALS). METHODS: We conducted a retrospective observational study, analyzing demographic data, lung function tests, and polysomnography (PSG) measures. Descriptive statistics, correlation analyses, and survival analyses were performed. RESULTS: = 0.0059). Spinal onset, a slower rate of FVC decline in the months preceding PSG and a preserved FVC (≥ 70%) at the time of PSG were associated with improved survival. CONCLUSION: We observed substantial sleep disturbances in our cohort overall with substantially increased arousals in the spinal group. FVC is a significant predictor for sleep efficiency and the decline in FVC is linked to survival.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Allen Institute for Brain Science (US), VIB-KU Leuven Center for Cancer Biology (BE), Shenzhen Chronic Disease Prevention Center (CN), VIB-KU Leuven Center for Microbiology (BE), VIB-KU Leuven Center for Brain & Disease Research (BE), University Psychiatric Hospital (SI), KU Leuven (BE)
Fonds Wetenschappelijk Onderzoek, KU Leuven, Onderzoeksraad, KU Leuven, Institut du Cerveau et de la Moelle Epinière
Good health and well-being
Openalex Percentile: Top 6%
Amyotrophic Lateral Sclerosis Research
DOISourceOpenAlex
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