Integrative analysis reveals intra-tumoral microbial enterotypes shape host transcriptomes in colorectal cancer
T cell exhaustion and immune evasion. These findings reveal that intra-tumoral microbiota influence host transcriptomes and immune modulation in CRC, supporting microbiome-based molecular stratification and offering insights into potential microbiota-targeted therapies.
Authors
- Pingmei Huang (ORCID: https://orcid.org/0000-0002-4893-8159)
- Xiaoning Yang
- Yifan Lian
- Shuntian Cai (ORCID: https://orcid.org/0000-0002-9951-4225)
- Yapi Lu
- Yanyun Fan
- Xiao Ding
- Fang Cao
- Kai Yuan
- Qinggui Chen
- Zhijian Ye
- Hongzhi Xu
- Xiang Zhang
- Sibo Yuan
- Jinbo Fu
- Luyao Wang (ORCID: https://orcid.org/0000-0003-0917-1749)
- Jianlin Ren
- Dan Du
- Huan Yang
Institutions
- Chinese University of Hong Kong (HK)
- Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1016/j.celrep.2026.117413
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Key Technologies Research and Development Program