Mutational and Expressional Deregulation of the <i>CHEK1</i> Gene in Breast Cancer Patients

BACKGROUND: Breast cancer burden is increasing day by day. The identification of novel genetic markers based on polymorphism and expression analysis is necessary to reduce the suffering of patients. AIMS: gene was assessed at the mRNA level. METHODS: gene was assessed in 200 breast tumors along with their adjacent uninvolved healthy tissue using quantitative real time (RT) PCR. RESULTS: < 0.0001) in breast tumor tissues as compared to adjacent control tissues. CONCLUSION: gene also plays an important role in chemotherapy resistance response among the Pakistani population.