Airway segmentation on CT – A systematic review of machine learning tools

<h2>Abstract</h2><h3>Background</h3> Airway assessment on computed tomography (CT) can yield clinically useful information for diagnosis, treatment planning and monitoring in respiratory diseases. Manual airway segmentation is time-consuming, prone to error and poorly reproducible. This systematic review aimed to appraise machine learning (ML) methods for fully automated airway segmentation in chest CT imaging. <h3>Methods</h3> EMBASE, MEDLINE and CENTRAL were searched on October 28, 2025, for studies which used fully automated ML methods for airway segmentation on CT and reported quantitative performance metrics. The quality of included studies was assessed by the Must AI Criteria-10 (MAIC-10) checklist. PROSPERO [CRD42025635504] <h3>Results</h3> Thirty-two studies (28 used deep learning (DL)) published between 2010 and 2025 were included. Airway segmentation was performed on non-contrast CT scans in most studies. Voxel-wise accuracy metrics were generally high with Dice similarity coefficient (DSC) values ranging between 83% and 96%. Airway-specific topological metrics: branch detection rate (BD) and tree length detection rate (TD) showed broader variability (60–95% and 54–95% respectively), with DL methods consistently outperforming classical ML approaches. Fifteen studies conducted external validation (EXACT'09 test set used in 9/15). MAIC-10 was moderate and ranged from 6 to 8 out of 10, with lowest reporting in safety/privacy (31%), explainability (31%) and transparency (53%). <h3>Conclusion</h3> ML models achieved strong airway segmentation accuracy but showed considerable variation in topological completeness. Standardised evaluation frameworks and the adoption of more diverse datasets are needed to strengthen model generalisability and support translation into clinical practice.