Low expression of miR-126 constitutes a risk factor for perioperative respiratory adverse events among pediatric patients under general anesthesia

AIM: This study aims to investigate the diagnostic value of miR-126 in Perioperative respiratory adverse events (PRAEs). METHODS: This study included 228 pediatric patients undergoing anesthesia and surgery, who were divided into two groups based on the occurrence of PRAEs. RT-qPCR was used to detect miR-126 levels, the CCK-8 assay was employed to evaluate cell proliferation capacity, and ELISA kits were utilized to measure TNF-α, IL-6, and IL-13 concentrations. The diagnostic value of miR-126 was assessed through receiver operating characteristic curve analysis. RESULTS: miR-126 is significantly downregulated in the serum of children with PAREs. Low expression of miR-126 is one of the risk factors for PRAEs occurrence. miR-126 level shows a negative correlation with the inflammatory levels in children with PRAEs. Overexpression of miR-126 promotes cell proliferation activity. CONCLUSION: miR-126 may contribute to the suppression of PRAEs by regulating proliferation and inflammatory responses in BEAS-2B cells and may serve as a diagnostic biomarker.