Extensively drug-resistant (XDR) Neisseria gonorrhoeae cured with ceftriaxone 2 g intravenous monotherapy in Croatia, March 2026
In early 2026 in Croatia, a male heterosexual patient of Croatian origin was diagnosed with extensively drug-resistant (XDR) gonorrhoea after unprotected vaginal intercourse with a Croatian female. The Neisseria gonorrhoeae HR027 isolate (genomic lineage B, MLST sequence type (ST)9903) exhibited high-level azithromycin, ceftriaxone, cefixime, benzylpenicillin, ciprofloxacin and tetracycline resistance. It had the mosaic penA -60.001 allele, and A2045G mutations in 23S rRNA. A single dose of ceftriaxone 2 g administered intravenously cured the infection. HR027 showed zoliflodacin and gepotidacin wild-type minimum inhibitory concentrations.
Authors
- М Унемо
- Iskra Alexandra Nola (ORCID: https://orcid.org/0000-0002-8268-210X)
- Ljiljana Žmak (ORCID: https://orcid.org/0000-0002-8354-3945)
- Ivana Ferenčak (ORCID: https://orcid.org/0000-0002-9285-9052)
- Ivana Božičević (ORCID: https://orcid.org/0000-0002-2263-4464)
- Daniel Golparian (ORCID: https://orcid.org/0000-0002-0688-2521)
- Dolores Peruč (ORCID: https://orcid.org/0000-0002-1933-2692)
- Nilia Volarević
- Daniela Glažar Ivče (ORCID: https://orcid.org/0000-0001-6923-0523)
- Dragan Jurić (ORCID: https://orcid.org/0009-0000-6564-1616)
- Tajana Juzbašić (ORCID: https://orcid.org/0009-0007-1937-7181)
- Susanne Jacobsson
- Tatjana Nemeth Blažić
- Ivana Bešlić
Institutions
- University of Zagreb (HR)
- Örebro University (SE)
- Hrvatski zavod za javno zdravstvo (HR)
- Andrija Stampar Teaching Institute of Public Health (HR)
- as2con (Croatia) (HR)
- University College London (GB)
Publication Details
- Journal
- Eurosurveillance
- Published
- 2026-05-28
- DOI
- https://doi.org/10.2807/1560-7917.es.2026.31.21.2600422
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00