Parkinson’s disease-subjective cognitive decline and health-related quality of life

BACKGROUND: Parkinson's disease-subjective cognitive decline (PD-SCD) is defined by subjective cognitive complaints (SCC) in the absence of objective cognitive impairment and has been associated with an increased risk of future cognitive decline. However, its impact on health-related quality of life (HRQoL) remains unclear. This is particularly relevant in early PD, when patients often maintain high levels of social-occupational functioning and subtle cognitive concerns may interfere with daily life. This study aimed to explore the association between SCC and HRQoL in cognitively unimpaired PD patients (PD-SCD). METHODS: Cross-sectional data from the COPPADIS cohort were analyzed. Patients with normal cognition according to PD-MCI level I criteria (Parkinson's Disease-Cognitive Rating Scale > 81) were included. HRQoL was assessed using the 39-item Parkinson's Disease Questionnaire (PDQ-39). SCC were defined as a Non-Motor Symptoms Scale (NMSS) domain 5 ≥ 1. RESULTS: A total of 497 patients with median age 62 years, disease duration 4 years, and 61% of PD-SCD were included. HRQoL was significantly worse in PD-SCD patients across all PDQ-39 domains. In adjusted linear regression models, PD-SCD was independently associated with higher PDQ-39 total score as well as with worse scores in activities of daily living, social support, cognition, and communication domains. CONCLUSIONS: PD-SCD is independently associated with poorer HRQoL across multiple domains. These findings highlight the clinical relevance of SCC within a patient-centered approach to PD management.

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Journal
Journal of Neural Transmission
Published
2026-05-29
DOI
https://doi.org/10.1007/s00702-026-03183-3
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
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article

Parkinson’s disease-subjective cognitive decline and health-related quality of life

Bárbara Vives, Jon Infante, Guillermo González‐Ortega, Caridad Valero Merino et al.
Journal of Neural Transmission
Parkinson's Disease Mechanisms and Treatments
article

Parkinson’s disease-subjective cognitive decline and health-related quality of life

Bárbara Vives, Jon Infante, Guillermo González‐Ortega, Caridad Valero Merino, Iria Cabo, Berta Solano Vila, Pilar Sánchez Alonso, A.M. Castellano Guerrero, María Asunción Ávila-Rivera, Juan García Caldentey, Carmen Borrué, Rubén Alonso Redondo, D. Macías García, Itziar Gastón, Lidia Bojtos, R. García- Ramos, N. Lopez Ariztegui, Manuel Seijo, Carlos Ordás, C. Borrué, Javier Ruiz Martínez, P. Franco Rosado, F. Lacruz, I. Cabo López, C. Labandeira, M. A. Ávila, B. González García, M. Kurtis, M. Gallego, P. Clavero, C. Cabello González, M. J. González Palmás, E. Casas, A. Cots Foraster, F. Carrillo, Y. Macías, J. Infante, S. Lucas del Pozo, P. Gámez, A. Alonso Cánovas, Rocío García-Ramos, Jon Rodríguez-Antigüedad, Jorge Hernandez-Vara, M. Álvarez Sauco, L. López Manzanares, P. Díaz Galván, N. López Ariztegui, E. López Valdés, P. Gómez Garre, I. González Aramburu, J. Hernández Vara, J. Kulisevsky, E. Carabajal Pendón, A. C. Luque Ambrosiani, S. Escalante, T. de Deus Fonticoba, Esther Cubo, COPPADIS Study Group, Lydia López Manzanares, M. G. Alonso Losada, M. Grau Solá, M. A. Mandrá, M. Mata, Nuria Caballol, J. González Aloy, A. Aldaz, Sonia Escalante, D. López Domínguez, A. Golpe Díaz, Manuel Menéndez-González, A. Fernández, A. Ascunce Vidondo, María Álvarez Sauco, M. Almarcha Menargues, G. Guardia Valls, I. Gastón, A. D. Adarmes-Gómez, Mónica Kurtis, Lydia Vela, J. García Caldentey, J. Castejón Carbó, R. Alonso Redondo, Pablo Mir, E. Estelrich Peyret, Carla Franch-Marti, N. Caballol, Arnau Puig-Davi, Saül Martínez-Horta, J. Dotor García-Soto, I. Legarda Ramírez, S. Jesús, E. Cubo, Julio Dotor García-Soto, Alfredo Puy Núñez, Juan Carlos Martínez Castrillo, Gracia Pons Pons, M. Almeria Vivó, Diego Santos-García, Javier Pagonabarraga, María G. Alonso Losada
article en

Abstract

BACKGROUND: Parkinson's disease-subjective cognitive decline (PD-SCD) is defined by subjective cognitive complaints (SCC) in the absence of objective cognitive impairment and has been associated with an increased risk of future cognitive decline. However, its impact on health-related quality of life (HRQoL) remains unclear. This is particularly relevant in early PD, when patients often maintain high levels of social-occupational functioning and subtle cognitive concerns may interfere with daily life. This study aimed to explore the association between SCC and HRQoL in cognitively unimpaired PD patients (PD-SCD). METHODS: Cross-sectional data from the COPPADIS cohort were analyzed. Patients with normal cognition according to PD-MCI level I criteria (Parkinson's Disease-Cognitive Rating Scale > 81) were included. HRQoL was assessed using the 39-item Parkinson's Disease Questionnaire (PDQ-39). SCC were defined as a Non-Motor Symptoms Scale (NMSS) domain 5 ≥ 1. RESULTS: A total of 497 patients with median age 62 years, disease duration 4 years, and 61% of PD-SCD were included. HRQoL was significantly worse in PD-SCD patients across all PDQ-39 domains. In adjusted linear regression models, PD-SCD was independently associated with higher PDQ-39 total score as well as with worse scores in activities of daily living, social support, cognition, and communication domains. CONCLUSIONS: PD-SCD is independently associated with poorer HRQoL across multiple domains. These findings highlight the clinical relevance of SCC within a patient-centered approach to PD management.

Journal of Neural Transmission
Hebron University (PS), Universitat Autònoma de Barcelona (ES), Hospital de Sant Pau (ES), University Hospital Complex Of Vigo (ES), Hospital Clínico San Carlos (ES), Biomedical Research Networking Center on Neurodegenerative Diseases (ES), Hospital Universitario Virgen Macarena (ES), Complejo Hospitalario de Navarra (ES), Marqués de Valdecilla University Hospital (ES), Hospital Universitario Fundación Alcorcón (ES), Hospital Universitario Rey Juan Carlos (ES), Institut de Recerca Biomèdica Catalunya Sud (ES), Vall d'Hebron Institut de Recerca (ES), Hospital Universitario Puerta de Hierro Majadahonda (ES), Hospital Universitario de Burgos (ES), Hospital General Universitario de Elche (ES), Hospital Arnau de Vilanova (ES), Vall d'Hebron Hospital Universitari (ES), Mútua Terrassa (ES), Hospital Universitario de La Princesa (ES), Hospital de Sant Joan Despí Moisès Broggi (ES), Clinica Rotger (ES), Hospital Universitario Central de Asturias (ES), Biomedical Research Institute (US), Donostiako Unibertsitate Ospitalea (ES), Complexo Hospitalario Universitario A Coruña (ES), Hospital Universitario Lucus Augusti (ES), Hospital Ruber Internacional (ES), Hospital Universitari de Tortosa Verge de la Cinta (ES), Hospital Universitario Son Espases (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Universitario de Móstoles (ES), Complejo Hospitalario de Pontevedra (ES), Instituto de Investigación Biomédica de A Coruña (ES), Hospital Universitario Infanta Sofía (ES), Institut d'Assistència Sanitària (ES), Hospital Universitario Ramón y Cajal (ES), Complejo Hospitalario Universitario de Toledo (ES), Complejo Hospitalario Universitario de Ferrol (ES), Universidad de Sevilla (ES)
Universitat Autònoma de Barcelona
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Parkinson's Disease Mechanisms and Treatments
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