Mortality trends and demographic disparities in breast cancer deaths with co-existing diabetes mellitus among U.S. adults ≥45 years, 1999–2020.

e13135 Background: Breast cancer stands out as a considerable cause of mortality attributed to cancer, and diabetes mellitus is a prevalent health issue that can lead to detrimental consequences. Existing literature provides an insufficient overview of the patterns and differences in mortality rates associated with breast cancer, in the presence of diabetes mellitus, within the older demographic. Methods: Data regarding mortality from the CDC WONDER spanning 1999 to 2020 were scrutinized, focusing on the relevant cohort of United States (US) individuals aged 45 and above. Fatalities were identified using malignant neoplasm of the breast as the underlying cause of death UCD (ICD-10 code C50), coupled with diabetes mellitus as a contributory cause of death (ICD-10 codes E10 to E14). Age-adjusted mortality rates (AAMR) per 100,000 were determined utilizing the 2000 United States Standard Population. All evaluations were segmented by gender, age ranges, state, and classification of urban or rural. Crude rated were determined for ten-year age group stratification. Results: Between 1999 and 2020, a total of 65419 death rates from breast cancer and diabetes-related conditions were reported in US adults aged 45 and older. Between 1990 and 2018 the total deaths decreased. Still, in 2020, there was a significant increase, bringing the average yearly death rate to 3.0 per 100,000 people. The total death toll among men (1999-2020) was 1,008, with a steady average yearly mortality rate of 0.1 per 100,000 people in both 1999 and 2020. Among women total death toll (1999-2020) was 64411, AAMRs rose slightly from 1999 to 2004 (APC 1.27%), declined from 2004 to 2018 (APC −1.59%), then increased sharply from 2018 to 2020 (APC 13.97%). The basic death rates rose significantly with increasing age (per 100,000): 0.3 for ages 45–54, 1.1 for ages 55–64, 3.1 for ages 65–74, 7.2 for ages 75–84, and 14.0 for those 85 and older. The highest average yearly mortality rates per state were observed in the District of Columbia (4.3), Ohio (4.0), Nebraska (3.8), Mississippi (3.7), Oklahoma (3.7), and West Virginia (3.6). Conclusions: Mortality trends among U. S. Adults, due to breast cancer deaths with concurrent diabetes among adults aged 45 years and older, has decreased in the last two decades but has risen markedly in recent years. Deaths were more common among those above 60 years of age, women, nonmetropolitan inhabitants, in addition to people living in particular states. The recent increase in mortality rate and disparities among age groups, gender and states emphasize the necessity of all-encompassing strategies for handling breast cancer and diabetes.