Stereoselective Synthesis of Thiocyanato/Selenocyanato‐Containing <i>Z</i> ‐Vinyl Sulfides Via Tf <sub>2</sub> O/DMSO‐Promoted Sulfenofunctionalization of Alkynes
In this work, we developed a practical sulfonium‐salt mediated difunctionalization of alkynes with NH 4 SCN/KSeCN. This method enables the effective synthesis of various thiocyanato/selenocyanato (SCN/SeCN)‐containing vinyl sulfides using DMSO as a readily available methylthio source. The reaction exhibits excellent regio‐ and Z‐selectivity with a broad substrate scope and high functional group compatibility. Gram‐scale experiments and late‐stage functionalization further make this protocol quite attractive in organic synthesis.
Authors
- Xiang-Qin Xu
- Zheng‐wu Tan
- Hong Yang (ORCID: https://orcid.org/0000-0003-0307-3494)
- Li‐Hua Yang (ORCID: https://orcid.org/0000-0001-7106-3015)
- Long‐Yong Xie (ORCID: https://orcid.org/0000-0002-8932-7282)
Institutions
- Hunan University of Science and Engineering (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2026-05-28
- DOI
- https://doi.org/10.1002/ejoc.70585
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00