Salvage Neck Dissection in the Acute Management of Refractory Cervical Lymphadenopathy for Interleukin-12 Receptor Beta 1 Patient: A Case Presentation

Abstract In patients with interleukin-12 receptor beta 1 deficiency, recurrent Salmonella infections can lead to refractory cervical lymphadenopathy unresponsive to antibiotics. This case report details the surgical intervention in a patient with IL12RB1 deficiency presenting with severe cervical lymphadenopathy. A 17-year-old male with a history of IL12RB1 deficiency, recurrent salmonella bacteremia, and lymphadenitis presented with high-grade fever and bilateral cervical lymph node enlargement. Despite prolonged antibiotic therapy, his condition deteriorated, necessitating surgical intervention. A neck dissection was performed, which significantly improved the infection symptoms and inflammation. The surgery resulted in the successful management of the infection, with a marked reduction in fever and inflammatory markers. Cultures postsurgery showed no growth, indicating the removal of the infection source. This case highlights the potential of surgical intervention as a critical management option for patients with severe immunodeficiency and recurrent infections when conventional medical therapies fail. It underscores the importance of considering early surgical options in similar cases to prevent further complications and improve patient outcomes.