Case report: Intravitreal Aflibercept for Refractory Irvine–Gass Syndrome

Abstract Background: Irvine–Gass syndrome (pseudophakic cystoid macular edema) is a common postoperative complication of cataract surgery. While most cases resolve with topical therapy, refractory cases pose a therapeutic challenge. Case Presentation: A 60-year-old woman developed bilateral cystoid macular edema several weeks after uneventful phacoemulsification. Initial postoperative visual acuity was 20/20 bilaterally, declining to 20/100 despite topical corticosteroids and NSAIDs. Optical coherence tomography confirmed significant intraretinal cystic changes. Intervention: Bilateral intravitreal aflibercept (2.0 mg/0.05 mL) was administered. Outcome: Two weeks post-injection, OCT demonstrated complete resolution of edema with restoration of best-corrected visual acuity to 20/20. Conclusion: Intravitreal aflibercept may be an effective treatment option for refractory Irvine–Gass syndrome. Keywords: cystoid macular edema, Irvine-Gass syndrome, Anti-VEGF, Optical Coherence Tomography, Cataract Surgery.