Serum metabolic biomarkers associated with self-reported chronic rhinosinusitis: a population-based cross-sectional study from the KNHANES

Objectives Chronic Rhinosinusitis (CRS) is a prevalent condition with complex pathophysiology. While metabolic factors have been suggested to play a role in CRS, the relationship between serum metabolic markers and CRS prevalence remains unclear. Methods This cross-sectional study used data from the 2022 Korean National Health and Nutrition Examination Survey to assess the relationship between serum lipid profiles, glucose metabolism, purine metabolism, and CRS prevalence. A total of 4,759 participants with complete data were included. CRS diagnosis was determined based on self-reported information obtained during health interviews. Serum metabolic markers were measured from fasting blood samples. Logistic regression analyses were conducted to calculate Odds Ratios (OR) and 95% Confidence Intervals (95% CI), while controlling for potential confounding factors. Results After controlling for confounders, high serum Uric Acid (UA) levels were significantly associated with a higher risk of CRS (OR = 1.558, 95% CI 1.040, 2.332, p = 0.020). Subgroup analysis revealed a stronger correlation among urban residents (OR = 1.635, 95% CI 1.085, 2.463, p = 0.019). However, no marked association was identified between serum indices of lipid metabolism and glucose metabolism and the prevalence of CRS. Conclusion This study found that higher serum UA levels were associated with the presence of CRS, suggesting a potential link between metabolic dysregulation and CRS susceptibility. Further longitudinal and experimental studies are needed to confirm these associations and clarify the underlying mechanisms. Level of evidence Level 4 (Cross-sectional study).