Precision suicide prevention requires mechanism-based therapeutics

Suicide is a major public health problem worldwide, with over 740,000 people dying by suicide globally each year, which averages to one death every 43 s [1]. Suicide ranks as a leading cause of death among 15–29-year-olds worldwide [2]. These rates have prompted increasing clinical and research resources, as evidenced by the Veterans Administration (VA), the largest health care system in the United States, which has prioritized suicide prevention as its number one clinical priority in addition to multiple national strategy programs across countries worldwide.