Evaluation of the Safety and Efficacy of SOF/VEL Treatment and Pre-treatment of TAF in Patients with Chronic Hepatitis B Virus/Hepatitis C Virus Coinfection: A Multicenter Study

Hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infection are among the leading causes of chronic liver diseases worldwide. Through the same transmission routes, HBV/HCV coinfection is widespread and aggravates liver damage. In this study, we aimed to assess the safety and efficacy of sofosbuvir/velpatasvir (SOF/VEL) and the pre-treatment of tenofovir alafenamide fumarate (TAF) on HBV reactivation in HBV/HCV coinfected patients.

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Publication Details

Journal
Journal of Clinical and Translational Hepatology
Published
2026-05-29
DOI
https://doi.org/10.14218/jcth.2026.00168
Primary Topic
Hepatitis B Virus Studies
Type
article
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article

Evaluation of the Safety and Efficacy of SOF/VEL Treatment and Pre-treatment of TAF in Patients with Chronic Hepatitis B Virus/Hepatitis C Virus Coinfection: A Multicenter Study

Zhan Zeng, 江应安, 黄祖雄, Songsong Xie et al.
Journal of Clinical and Translational Hepatology
Hepatitis B Virus Studies
article

Evaluation of the Safety and Efficacy of SOF/VEL Treatment and Pre-treatment of TAF in Patients with Chronic Hepatitis B Virus/Hepatitis C Virus Coinfection: A Multicenter Study

Zhan Zeng, 江应安, 黄祖雄, Songsong Xie, Jiawei Geng, Liting Zhang, Xiaobo Lu, Yanyan Yu, Ning Lin, Yuemin Nan, Hong You, Qian Kang, Xiaoyuan Xu, Liaoyun Zhang, Minghua Su, Jia Shang, Biao Wu, Dazhi Zhang, Chengzhen Lu, Yifan Han, Hongyu Chen, Zhili Wen
article en

Abstract

Hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infection are among the leading causes of chronic liver diseases worldwide. Through the same transmission routes, HBV/HCV coinfection is widespread and aggravates liver damage. In this study, we aimed to assess the safety and efficacy of sofosbuvir/velpatasvir (SOF/VEL) and the pre-treatment of tenofovir alafenamide fumarate (TAF) on HBV reactivation in HBV/HCV coinfected patients.

Journal of Clinical and Translational HepatologyVol. 000(000)
Good health and well-being
Openalex Percentile: Top 7%
Hepatitis B Virus Studies
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