Association of Chemerin, follicle stimulating hormone, lipid profiles, and cardiometabolic indices with the premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a reproductive endocrine disorder characterized by amenorrhea, hypergonadotropism, and hypoestrogenism before age 40. This study investigated the association of serum Chemerin, follicle stimulating hormone, lipid profile and cardiometabolic indices with the POI. In this case-control study, 38 women with POI and 38 controls were assessed for anthropometric parameters, serum Chemerin, FSH, lipid profile and cardiometabolic indices. Associations were examined using multivariable logistic regression models. Discriminative performance was evaluated using receiver operating characteristic (ROC) analysis and a combined multivariable model. POI was significantly associated with educational years, physical activity, total cholesterol (TC), triglyceride (TG) and serum Chemerin levels (P < 0.05). ROC analysis showed moderate discriminative ability for Chemerin, TC, and TG, with optimal cut-offs of 25.14 ng/L for serum Chemerin, 196.0 mg/dL for TC, and 114.5 mg/dL for TG, respectively. The combined multivariable model demonstrated excellent discrimination (AUC = 0.929; 95% CI 0.876-0.981), achieving 94.7% sensitivity and 76.3% specificity. Serum Chemerin showed moderate diagnostic value, while several individual variables also demonstrated moderate discriminative ability. However, the combined multivariable model showed substantially stronger discriminatory performance, indicating that integrating multiple variables improves the ability to identify POI compared with individual variables alone.