Real-world implementation of an integrated exercise medicine model within routine oncology care.

1577 Background: Exercise is an evidence-based intervention for people with cancer, with demonstrated benefits for physical function, symptom burden, and treatment tolerance. Despite international guideline recommendations, exercise remains inconsistently implemented as a prescribed medical treatment in routine oncology care. This study describes the real-world implementation of an integrated Exercise Medicine model embedded within a supportive oncology service. Methods: This descriptive implementation study reports on the Lift Model of Care, a clinician-led supportive cancer care service established in Australia in 2018. Exercise Medicine is delivered as a core, medically prescribed intervention and integrated with Physiotherapy, Psychology, Dietetics, and subspecialty services across the cancer continuum. Exercise prescriptions are individually tailored and dosed by qualified clinicians in accordance with Clinical Oncology Society of Australia exercise guidelines and delivered in a medically supervised environment. Routinely collected service data were analysed descriptively. The primary outcome was annual service reach and treatment volume from 2018 to 2025. Secondary outcomes included patient-reported experience measures related to Exercise Medicine. Results: Annual service reach increased from 607 individuals in 2018 to 1,353 individuals in 2025. Delivery of Exercise Medicine increased from 2,077 to 12,255 treatments annually, reflecting sustained growth in access and longitudinal engagement. Concurrent increases in Physiotherapy, Psychology, Dietetics, and Lymphoedema services were observed, supporting coordinated multidisciplinary care delivery. Patient-reported experience data demonstrated high acceptability, with over 90% of respondents reporting high satisfaction and perceived improvements in fatigue, strength, functional capacity, and ability to tolerate cancer treatment. Conclusions: This real-world implementation study demonstrates the feasibility of embedding Exercise Medicine as a prescribed treatment within routine oncology care at scale. The model provides a pragmatic framework for integrating guideline-recommended exercise into standard cancer pathways and may inform broader adoption across health systems.