Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified <scp> STAM3 <sup>m</sup> P </scp> Score
ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM 3 P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the modified “STAM3 m P score” in two independent cohorts ( n = 302). A STAM3 m P score ≥ 1 identified 96% of patients with treatment‐responsive RPD; ≥ 3 features were highly specific (98%). These data suggest that ≥ 1 STAM3 m P features effectively identifies treatment‐responsive RPD and may be used to prioritize investigations, whereas ≥ 3 STAM3 m P features are highly specific and may inform early treatment decisions.
Authors
- E.G.P. Dopper
- H. Seelaar
- P.A.E. Sillevis Smitt
- F A de Jong
- M. J. Titulaer
- S. Veenbergen
- N. Satyadev (ORCID: https://orcid.org/0000-0001-7302-2348)
- J. M. de Vries
- J. Kerstens
- A. E. M. Bastiaansen
- J. Brenner (ORCID: https://orcid.org/0000-0001-5523-4398)
- T. M. Bienfait
- Y. S. Crijnen (ORCID: https://orcid.org/0000-0003-0279-7140)
- G. S. Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Y. D. Piura
- T. Brand
- R. W. van Steenhoven (ORCID: https://orcid.org/0009-0003-6842-095X)
Institutions
- Jacksonville College (US)
- Erasmus MC (NL)
- Antwerp University Hospital (BE)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-05-27
- DOI
- https://doi.org/10.1002/acn3.70434
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00