AVITHRAPID - Standard Operating Procedure - Antiviral activity evaluation by CPE – Virucidal compounds

When evaluating the antiviral effect of a compound, assessing cellular toxicity in the target cell line is an essential prerequisite (see dedicated SOP). The highest dose allowing > 90 % cell viability is the first tested dose in antiviral assay. SARS-CoV-2, WNV and CHIKV infections on Vero E6 cell line causes a cytopathic effect (CPE) that can be used as a simple, low-cost first-line method for evaluating the antiviral efficacy of compounds.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-05-27
DOI
https://doi.org/10.5281/zenodo.20408028
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
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article

AVITHRAPID - Standard Operating Procedure - Antiviral activity evaluation by CPE – Virucidal compounds

Anne Bull-Maurer
Zenodo (CERN European Organization for Nuclear Research)
SARS-CoV-2 and COVID-19 Research
article

AVITHRAPID - Standard Operating Procedure - Antiviral activity evaluation by CPE – Virucidal compounds

Anne Bull-Maurer
article en

Abstract

When evaluating the antiviral effect of a compound, assessing cellular toxicity in the target cell line is an essential prerequisite (see dedicated SOP). The highest dose allowing > 90 % cell viability is the first tested dose in antiviral assay. SARS-CoV-2, WNV and CHIKV infections on Vero E6 cell line causes a cytopathic effect (CPE) that can be used as a simple, low-cost first-line method for evaluating the antiviral efficacy of compounds.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 6%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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AVITHRAPID - Standard Operating Procedure - Antiviral activity evaluation by CPE – Virucidal compounds — Anne Bull-Maurer · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS