A High-resolution metal–insulator–metal plasmonic biosensor with concentric ring resonators for carcinoembryonic antigen detection

High-resolution optical sensors are vital for detecting subtle refractive index variations associated with biomolecular interactions, such as changes in carcinoembryonic antigen (CEA) concentration. This work presents a compact metal-insulator-metal (MIM) plasmonic sensor with two concentric ring resonators, numerically investigated using finite-difference time-domain simulations. Structural parameters are optimized to maximize field confinement and resonant mode coupling, yielding a sensitivity of 1035 nm/RIU, a resonance linewidth of 3.75 nm, and a figure of merit of 276 RIU⁻¹. The sensor demonstrates precise spectral shifts corresponding to minute refractive index changes linked to CEA, while the influence of surface-bound layers and fabrication tolerances is also assessed to ensure robustness under practical conditions. These results highlight the sensor's potential as a high-resolution, label-free platform for monitoring CEA in biological samples.

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Publication Details

Journal
Scientific Reports
Published
2026-05-27
DOI
https://doi.org/10.1038/s41598-026-55336-9
Primary Topic
Plasmonic and Surface Plasmon Research
Type
article
Field-Weighted Citation Impact
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article

A High-resolution metal–insulator–metal plasmonic biosensor with concentric ring resonators for carcinoembryonic antigen detection

Azadeh Nilghaz, Hadi Izadiyar, Hamid Bahador
Scientific Reports
Plasmonic and Surface Plasmon Research
article

A High-resolution metal–insulator–metal plasmonic biosensor with concentric ring resonators for carcinoembryonic antigen detection

Azadeh Nilghaz, Hadi Izadiyar, Hamid Bahador
article en

Abstract

High-resolution optical sensors are vital for detecting subtle refractive index variations associated with biomolecular interactions, such as changes in carcinoembryonic antigen (CEA) concentration. This work presents a compact metal-insulator-metal (MIM) plasmonic sensor with two concentric ring resonators, numerically investigated using finite-difference time-domain simulations. Structural parameters are optimized to maximize field confinement and resonant mode coupling, yielding a sensitivity of 1035 nm/RIU, a resonance linewidth of 3.75 nm, and a figure of merit of 276 RIU⁻¹. The sensor demonstrates precise spectral shifts corresponding to minute refractive index changes linked to CEA, while the influence of surface-bound layers and fabrication tolerances is also assessed to ensure robustness under practical conditions. These results highlight the sensor's potential as a high-resolution, label-free platform for monitoring CEA in biological samples.

Scientific Reports
Monash University (AU), University of Mohaghegh Ardabili (IR)
Openalex Percentile: Top 10%
Plasmonic and Surface Plasmon Research
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