A High-resolution metal–insulator–metal plasmonic biosensor with concentric ring resonators for carcinoembryonic antigen detection
High-resolution optical sensors are vital for detecting subtle refractive index variations associated with biomolecular interactions, such as changes in carcinoembryonic antigen (CEA) concentration. This work presents a compact metal-insulator-metal (MIM) plasmonic sensor with two concentric ring resonators, numerically investigated using finite-difference time-domain simulations. Structural parameters are optimized to maximize field confinement and resonant mode coupling, yielding a sensitivity of 1035 nm/RIU, a resonance linewidth of 3.75 nm, and a figure of merit of 276 RIU⁻¹. The sensor demonstrates precise spectral shifts corresponding to minute refractive index changes linked to CEA, while the influence of surface-bound layers and fabrication tolerances is also assessed to ensure robustness under practical conditions. These results highlight the sensor's potential as a high-resolution, label-free platform for monitoring CEA in biological samples.
Authors
- Azadeh Nilghaz (ORCID: https://orcid.org/0000-0001-5769-7281)
- Hadi Izadiyar
- Hamid Bahador
Institutions
- Monash University (AU)
- University of Mohaghegh Ardabili (IR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-27
- DOI
- https://doi.org/10.1038/s41598-026-55336-9
- Primary Topic
- Plasmonic and Surface Plasmon Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00