Assessment of the primary skin irritation potential of Venusia Max lotion and cream: A controlled human patch test study

Objectives: This study evaluated the skin irritation potential of Venusia Max Cream and Venusia Max Lotion using a standardized human patch test in both normal and sensitive skin populations. Materials and Methods: In this single-center, non-randomized, single-blind, single-application, controlled study, approximately 0.04 g of cream and 0.04 g of lotion were applied occlusively on the backs of adult participants. Negative (0.9% isotonic saline) and positive (1% sodium lauryl sulfate) controls were included. Patches were removed after 24 h, and assessments were conducted at 48 and 72 h using the Draize scale. Participants with visible reactions were followed up after 1 week. Sensitive skin status was confirmed by the lactic acid sting test. Data were summarized using descriptive statistical methods. Results: Twenty-six participants (13 males, 13 females; mean age 30.88 ± 9.97 years), evenly divided into sensitive and normal skin groups, completed the study. At 48 h, mean cumulative irritation scores were 0.38 for Venusia Max Lotion and 0.27 for Venusia Max Cream; both further decreased at 72 h (0.23 and 0.04, respectively). All scores remained well below the irritancy threshold of 2.0. No adverse events or intolerances were observed in either normal or sensitive skin groups. Conclusion: Venusia Max Lotion and Cream were classified as “Non-Irritant” as per IS 4011: 2018 Methods of Test for Safety Evaluation of Cosmetics (Third Revision) guidelines. Both formulations demonstrated low irritation scores in normal and sensitive skin populations under controlled patch test conditions, indicating good dermal tolerability. From a consumer perspective, the key advantage lies in achieving consistent skin comfort and barrier support through daily moisturization, made possible by a gentle, non-irritant formulation.