Gene Expression Profiles at Early vs Late Stages After Cervical Artery Dissection
Cervical artery dissection (CeAD) is a common cause of stroke in young adults. While the pathogenesis of CeAD remains poorly understood, clinical and genetic associations suggest a systemic arteriopathy at the early phase of CeAD. We hypothesize that individuals experiencing CeAD express a distinct gene expression profile at the early phase compared with (1) age-matched and sex-matched controls and (2) late-phase profiles within the same individual at a later time point.
Authors
- Timothy L. McMurry (ORCID: https://orcid.org/0000-0001-5912-5092)
- Ilana E. Green (ORCID: https://orcid.org/0000-0002-7629-3124)
- Fang‐Chi Hsu (ORCID: https://orcid.org/0000-0001-6955-929X)
- Stefan Bekiranov (ORCID: https://orcid.org/0000-0002-3177-4346)
- Keith L. Keene (ORCID: https://orcid.org/0000-0002-7826-399X)
- Michèle M. Sale (ORCID: https://orcid.org/0000-0003-1644-9040)
- Glen C. Jickling (ORCID: https://orcid.org/0000-0003-3543-0820)
- Bradford B. Worrall
- Stephen R. Williams (ORCID: https://orcid.org/0000-0003-2108-2757)
- Robert B. Ferguson (ORCID: https://orcid.org/0009-0000-8015-7371)
- Andrew M. Southerland (ORCID: https://orcid.org/0000-0002-3646-358X)
- Hyacinth I. Hyacinth (ORCID: https://orcid.org/0000-0002-1991-7463)
Institutions
- Albert Einstein College of Medicine (US)
- University of Alberta (CA)
- East Carolina University (US)
- Wake Forest University (US)
- University of Virginia (US)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2026-05-27
- DOI
- https://doi.org/10.1212/nxg.0000000000200396
- Primary Topic
- Cervical and Thoracic Myelopathy
- Type
- article
- Field-Weighted Citation Impact
- 0.00