The role of miRNA in modulating oxidative stress in Preeclampsia: current knowledge

Preeclampsia (PE), a gestational disorder diagnosed with hypertension and proteinuria, is recognized as a significant cause of both maternal and perinatal morbidity and mortality around the world. Oxidative stress (OS) is found to act as a major positive role in PE progression, which is regulated by the function derived from multiple microRNAs (miRNAs), a group of cellular small endogenous RNAs that modulate gene expression at post-transcriptional level. This review summarizes the role of different miRNAs in the PE development, focusing on their involvement in OS regulation. In addition, the paper also discusses the current knowledge of the molecular mechanisms regarding to PE and highlights the possible therapeutic implications of targeting miRNAs in the management of this condition.