Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report
Lung function peaks in young adulthood and declines with age. Studies suggest that this trajectory may be modifiable, potentially enhancing lung health and resilience to prevent or delay the onset of chronic lung disease. Although significant progress has been made in identifying the lung stem/progenitor cell populations involved in lung repair and homeostasis, their regulation and potential for manipulation to promote respiratory health and resilience remain elusive. To explore these issues, the NHLBI organized a virtual workshop on November 7-8, 2024 that aimed to cover the current scientific landscape, address critical research gaps, and identify challenges, opportunities, and key research questions related to chronic lung disease, with a focus on lung stem/progenitor resilience and its applications in the early diagnosis, prevention, and treatment of chronic lung diseases. This report summarizes the scientific presentations, discussions, and recommendations from the workshop.
Authors
- A. M. Jamieson (ORCID: https://orcid.org/0000-0002-5781-9231)
- John F. Engelhardt (ORCID: https://orcid.org/0000-0003-2389-9277)
- Jeong H. Yun (ORCID: https://orcid.org/0000-0002-4361-8295)
- Mingxia Gu (ORCID: https://orcid.org/0000-0001-7405-8473)
- Yohannes Tesfaigzi (ORCID: https://orcid.org/0000-0002-3997-5839)
- Andrew A. Wilson (ORCID: https://orcid.org/0000-0003-3406-9906)
- Preetish Kadur Lakshminarasimha Murthy (ORCID: https://orcid.org/0000-0002-9762-8376)
- Maria C. Basil (ORCID: https://orcid.org/0000-0003-4716-1285)
- Dianhua Jiang (ORCID: https://orcid.org/0000-0002-4508-3829)
- Christian R. Gómez (ORCID: https://orcid.org/0000-0001-5323-9507)
- Susan M. Majka (ORCID: https://orcid.org/0000-0002-1005-1552)
- Ruobing Wang (ORCID: https://orcid.org/0000-0003-0277-8329)
- Moumita Ghosh (ORCID: https://orcid.org/0009-0000-8442-8044)
- Anny Xiaobo Zhou
- Jose Ordovas-Montanes
- Helen Miranda
- H Schiller
- SeungHye Han (ORCID: https://orcid.org/0000-0001-5625-6337)
- Purushothama Rao Tata
- Daniel J Weiss
- Shawn Davidson
- Micha Sam Brickman Raredon
- Qing Lu
- Jayaraj Rajagopal
- Harold Chapman
- Jianwen Que
- Frank McKeon
- Bin Zhou
- Ravi Kalhan
Institutions
- Broad Institute (US)
- Boston University (US)
- University of Vermont (US)
- Northwestern University (US)
- Cedars-Sinai Medical Center (US)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- Duke University (US)
- University of California, San Francisco (US)
- Brown University (US)
- University of California System (US)
- National Jewish Health (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Northwestern University (PH)
- National Heart, Lung, and Blood Institute (US)
- Regenerative Medical Solutions (United States) (US)
- Center for Excellence in Molecular Cell Science (CN)
- German Center for Lung Research (DE)
- Northwestern Medicine (US)
- Harvard Stem Cell Institute (US)
- University of Houston (US)
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- University of Colorado Denver (US)
- Philadelphia University (US)
Publication Details
- Journal
- American Journal of Respiratory Cell and Molecular Biology
- Published
- 2026-05-27
- DOI
- https://doi.org/10.1093/ajrcmb/aanag107
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00