PPP1R14B promotes ferroptosis resistance via YAP1/SLC3A2 signaling in cervical cancer

Cervical cancer is one of the most common malignant tumors in women, but treatment options are limited. Previous studies have shown that ferroptosis plays a crucial part in the development of various cancers, and inducing ferroptosis in cancer cells can effectively suppress tumor growth. However, research on ferroptosis in cervical cancer is scarce, and the specific mechanisms involved are not well understood. In this study, we found a significant correlation between PPP1R14B and poor prognosis in cervical cancer. Both in vitro and in vivo experiments demonstrated that PPP1R14B promotes the progression of cervical cancer and enhances the resistance of cervical cancer cells to ferroptosis induction. Mechanistically, PPP1R14B upregulates the SLC3A2 expression, thereby inhibiting ferroptosis in cancer cells. Additionally, PPP1R14B activates the YAP1 signaling pathway, which can bind to the SLC3A2 promoter to regulate the content of ROS, MDA, and GSH in cancer cells. Overall, our study suggested that PPP1R14B is a potential therapeutic target for cervical cancer and highlights its role in inhibiting ferroptosis.