A miniaturized implantable electrochemical platform for continuous monitoring of metabolites in deep tissue

The loss or suppression of local metabolic function in living tissues brought about by a lack of oxygen availability (ischemia) serves as the origin for myriad life-threatening conditions including stroke, heart failure, and peripheral ischemic injury. Despite the pressing clinical need to evaluate local tissue health, platforms that support such analysis remain elusive. To address this need, we present a wireless, minimally invasive, multianalyte, electrochemical probe supporting the continuous profiling of local metabolites including K + and pH, and the semicontinuous profiling of lactic acid. We validate the analytical capabilities of our sensing system by ion profiling in arterial whole blood. Furthermore, we use acute compartment syndrome as a model for tissue ischemia and use our percutaneously implanted probes to track metabolic changes in living muscle in real time.

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Publication Details

Journal
Science Advances
Published
2026-05-27
DOI
https://doi.org/10.1126/sciadv.adz8930
Primary Topic
Analytical Chemistry and Sensors
Type
article
Field-Weighted Citation Impact
0.00

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article

A miniaturized implantable electrochemical platform for continuous monitoring of metabolites in deep tissue

Soongwon Cho, Joanna L. Ciatti, Kenneth E. Madsen, M.A. Pet et al.
Science Advances
Analytical Chemistry and Sensors
article

A miniaturized implantable electrochemical platform for continuous monitoring of metabolites in deep tissue

Soongwon Cho, Joanna L. Ciatti, Kenneth E. Madsen, M.A. Pet, Dane Hintermueller, J A Rogers, Sara Saffari, Joseph G. Ribaudo, Amanda M. Westman, Ralph G. Nuzzo, Elliot A. Opel, Yu-Ting Huang
article en

Abstract

The loss or suppression of local metabolic function in living tissues brought about by a lack of oxygen availability (ischemia) serves as the origin for myriad life-threatening conditions including stroke, heart failure, and peripheral ischemic injury. Despite the pressing clinical need to evaluate local tissue health, platforms that support such analysis remain elusive. To address this need, we present a wireless, minimally invasive, multianalyte, electrochemical probe supporting the continuous profiling of local metabolites including K + and pH, and the semicontinuous profiling of lactic acid. We validate the analytical capabilities of our sensing system by ion profiling in arterial whole blood. Furthermore, we use acute compartment syndrome as a model for tissue ischemia and use our percutaneously implanted probes to track metabolic changes in living muscle in real time.

Science AdvancesVol. 12(22)
Northwestern University (US), University of Illinois Urbana-Champaign (US), Washington University in St. Louis (US), Neurological Surgery (US), KTH Royal Institute of Technology (SE)
National Institutes of Health, Materials Research Science and Engineering Center, Northwestern University
Good health and well-being
Openalex Percentile: Top 10%
Analytical Chemistry and Sensors
DOIOpen Access PDFOpenAlex
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