Green light relieves stress-induced anxiety-like behaviors via visual-to-prefrontal projections in mice
). Chemogenetic activation of this pathway mimics the anxiolytic effects of green light, whereas artificial inhibition of this pathway or pharmacological blockade of CRF receptor 1 (CRFR1) in the PrL abolishes green-light-induced anxiolysis in acute stress model mice. This study thus indicates a CRF-dependent neural mechanism underlying the anxiolytic effects of green light under stress conditions.
Authors
- Bojian Ye
- Ying Liu
- Jun-Ma Yu
- Ziyun Ni
- Mingjun Zhang
- An Liu
- Peng Cao
- Xu Wang
- Wenjuan Tao
- Zhi Zhang (ORCID: https://orcid.org/0000-0002-8637-8463)
- Songbin Liu
- Jun Ma
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-05-23
- DOI
- https://doi.org/10.1016/j.celrep.2026.117426
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China