The Impact of Continuous Renal Replacement Therapy Filters with Cytokine Adsorption Properties on Survival Outcomes: A Study Using Diagnosis Procedure Combination data

BACKGROUND: Continuous renal replacement therapy (CRRT) is one of the adjunctive therapies for sepsis. This study compared 30-day mortality between conventional hemofilter and the polyethyleneimine-coated polyacrylonitrile membrane (AN69ST) in intensive care unit. METHODS: Using the Diagnosis Procedure Combination (DPC) database provided by Medical Data Vision Co., Ltd. (MDV), our analysis focused on patients who underwent CRRT in ICU. The primary outcome was defined as the 30-day mortality rate. Patients were categorized into the AN69ST group and the non-AN69ST group. A subgroup analysis was performed. Furthermore, analysis was conducted considering changes in hemofilters to align with actual clinical practice. RESULTS: A total of 9,147 patients underwent CRRT, including 1,419 in the AN69ST group. The analysis demonstrated a statistically significant reduction in 30-day mortality in the AN69ST group (hazard ratio (HR) 0.825, 95% confidence interval (CI) 0.742-0.916).