Safety and Efficacy of Double-effect Kissing Balloon Technique in Left Main Bifurcation PCI: Design and Rationale of JDEPTH-LM Registry

INTRODUCTION: The JDEPTH-LM Registry is a prospective, multi-center observational study in 32 Japanese institutions evaluating the double-effect kissing balloon technique (W-KBT) as a novel strategy for left main trunk percutaneous coronary intervention (LM-PCI). This approach combines provisional crossover stenting, proximal optimization technique, KBT and prolonged (≥30-second) KBT using a perfusion balloon for the left anterior descending artery and a drug-coated balloon for the left circumflex (LCx) ostium. METHODS: A total of 280 patients with stable/unstable angina or non-ST-elevation myocardial infarction and LCx ostial involvement will be enrolled. The co-primary endpoints are procedural success and major adverse cardiovascular events at 12 months. The JDEPTH-LM Registry will provide clinical data on the safety and efficacy of W-KBT, which may enhance outcomes in LM-PCI involving the LCx ostial lesion. CONCLUSION: these findings could contribute to the optimization of complex LM-PCI strategies in clinical practice. Unique Identifier: NCT06436092, jRCT1030240071.