Multifaceted gold vanoparticles by bark extract of Sweetinia mahagoni and their potential antimicrobial, antioxidant, anticancer and antiviral applications

The current study of the biosynthesized Sm-AuNPs reveals a SPR peak at 554 nm indicating reduction of gold chloride to gold nanoparticles (Sm-AuNPs). Fourier Infrared Spectroscopy revealed that different bioactive compounds of bark extract were involved in reduction and stabilization of Sm-AuNPs. Transmission Electron Microscopy and EDX analysis of Sm-AuNPs reveals that the nanoparticles spherical in shape. The Sm-AuNPs are poly-dispersed in nature, with a poly-disperse index about 0.310 and high negative zeta potential value of -62.5 mV. The Sm-AuNPs reveals excellent antioxidant, antibacterial, anticancer activities and anti-viral properties. The results revealed that the Sm-AuNPs have an excellent antibacterial activity when compared with standard antibiotics while they also reveal a significant antioxidant activity. The anticancer studies on SKOV ovarian cancer cell line by Sm-AuNPs was carried by MTT assay, reveals that IC50 value was 64.19 µg/ml and the apoptotic cells were detected by Dual fluorescence assay. Apart from the above studies, the antiviral efficacy of Sm-AuNPs on New Castle Disease (NDV) was carried out in embryonated chicken eggs, reveals that the Sm-AuNPs have very good and considerable antiviral properties. The green synthesized Sm-AuNPs can useful as future therapeutic agents to control cancer and NDV effectively.