Effects of fecal microbiota transplantation and probiotics on the gut microbiome in antibiotic-treated septic patients: A pilot randomized controlled trial
= 0.021). Donor-recipient analysis showed FMT shifted recipient microbiomes toward donor enterotype. This study provides preliminary evidence that FMT, but not the probiotic regimen, effectively restores gut microbiome diversity and composition, reduces pathogenic potential, and may improve clinical outcomes in critically ill sepsis patients after broad-spectrum antibiotics. This study was registered on ClinicalTrials.gov (NCT05578196).
Authors
- Jiangman Zhao (ORCID: https://orcid.org/0000-0001-6572-6177)
- Yangyang Yin (ORCID: https://orcid.org/0000-0001-7317-160X)
- YuGang Zhuang
- Jin Zhao (ORCID: https://orcid.org/0000-0001-8751-428X)
- Hu Peng
- Yi Zhao (ORCID: https://orcid.org/0000-0002-3839-6499)
- Yanqing Chen (ORCID: https://orcid.org/0000-0002-9534-6199)
- Shi Dong
- Di Hao
- Sitong Lin
- Yuanzhuo Chen
- Shaohua Jia
- Qiyi Chen
Institutions
- Tongji University (CN)
- Shanghai Innovative Research Center of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Virulence
- Published
- 2026-05-22
- DOI
- https://doi.org/10.1080/21505594.2026.2668764
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00