Expression of <i>hsa_circ_0004928</i> in gastric cancer and prognostic significance

Abstract Objectives Circular RNAs are valuable biomarkers for cancer therapy. hsa_circ_0004928 expression is dysregulated in gastric cancer (GC). The study aims to further explore the roles of hsa_circ_0004928 in GC and the possible mechanism. Methods The expression of hsa_circ_0004928 in GC tissues and cells was analyzed via qRT-PCR. The predictive value of hsa_circ_0004928 for GC severity and prognosis was assessed. The interaction between hsa_circ_0004928 and miR-375 was verified by a database and confirmed using RIP. The impacts of hsa_circ_0004928 and miR-375 on GC cell function were evaluated. Results hsa_circ_0004928 was upregulated in GC. High hsa_circ_0004928 expression was related to advanced clinical symptoms of GC. hsa_circ_0004928 showed a significant positive correlation with common tumor markers, including CA199 , CEA , and CA724 . hsa_circ_0004928 was identified as an independent prognostic factor, with its high expression level associated with poorer survival outcomes. hsa_circ_0004928 demonstrated favorable predictive value in the diagnosis of GC. Furthermore, miR-375 was a potential target gene of hsa_circ_0004928 ; knockdown of hsa_circ_0004928 significantly inhibited the growth and metastasis of GC cells, while miR-375 reversed these effects. Conclusions hsa_circ_0004928 is closely linked to GC severity and is a promising prognostic and diagnostic indicator. hsa_circ_0004928 promotes GC progression via regulating miR-375 .