Granulation-driven modulation of improved advanced flow properties with immediate drug release using modified Eudragit EPO granules

AIM: This study aimed to improve the flowability and manufacturability of cohesive Eudragit EPO using wet granulation for immediate-release tablet formulations. METHODS: rPowder flow properties were evaluated using conventional micromeritic methods and advanced rheological analysis with a Brookfield Powder Flow Tester. Wet granulation was performed using 0.25% w/w hydroxypropyl methylcellulose, with and without isoniazid as a model drug. Granules and tablets were characterised for particle properties, solid-state behaviour, physicomechanical characteristics, and drug release. RESULTS: Raw Eudragit EPO exhibited poor flowability and high cohesiveness. Wet granulation significantly improved flow properties, increased particle size, and reduced surface area. Tablets prepared from optimised granules showed acceptable hardness, friability, disintegration, content uniformity, and complete drug release within 2 h in 0.1 N HCl. Solid-state analyses confirmed chemical compatibility and partial amorphization without degradation. CONCLUSIONS: Wet granulation effectively transformed Eudragit EPO into a free-flowing and compressible material suitable for immediate-release tablet manufacturing.