Flipping the Card With Enantiodivergent Organocatalysis

This minireview focuses on recent and most impactful contributions in enantiodivergent organocatalyzed reactions. Four different approaches based on achiral stimuli were examined as inversion strategies: solvent-controlled inversion, achiral reagent or additive-inducted inversion, and minimal catalyst modification, discussing in detail for each example the mechanistic insights behind the chiral inversion. Other strategies to achieve enantiodivergence are also briefly discussed.