FTO demethylates Cyclin E1/D1 mRNA and inhibits non-small cell lung cancer cell EMT and proliferation
A modification in NSCLC cells. FTO attenuates IGF2BP2-mediated mRNA stability of Cyclin E1 and Cyclin D1, supporting the notion that FTO suppresses EMT and proliferation in NSCLC cells via an IGF2BP2-dependent mechanism. Taken together, our findings highlight the critical role of FTO in regulating Cyclin E1 and Cyclin D1, and establish the interaction mechanism between FTO and Cyclin E1/Cyclin D1 in controlling EMT and proliferation in NSCLC cells.
Authors
- Jianbo Liu (ORCID: https://orcid.org/0000-0002-4477-0424)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Zheng Zhou (ORCID: https://orcid.org/0000-0002-3620-4721)
- Zelong Sun
- Leyang Shi
Institutions
- Second Affiliated Hospital of Zhengzhou University (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2026-05-22
- DOI
- https://doi.org/10.1016/j.cellsig.2026.112615
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Henan Province
- China Postdoctoral Science Foundation
- Science and Technology Department, Henan Province