Electrospun nanocomposite dressing integrating cerium dioxide and collagen accelerates pressure injury healing

<h2>Summary</h2> Pressure injuries (PIs) involve a pathological cycle of oxidative stress, inflammation, and impaired angiogenesis. To address this, we engineered an electrospun nanocomposite dressing—CePC—incorporating cerium dioxide nanoparticles into a polycaprolactone collagen matrix. This dressing could modulate the wound microenvironment. <i>In vitro</i>, it could scavenge reactive oxygen species, protect endothelial cells, enhance vascular endothelial growth factor (VEGF) expression, and reduce pro-inflammatory cytokines. In a murine PI model, the treatment accelerated wound closure, promoted granulation tissue formation and dermal regeneration, and improved functional angiogenesis. Mechanistically, the dressing shifted the macrophage phenotype from a pro-inflammatory to a pro-healing state. These findings demonstrate a strategy that combines nanomaterials and biomaterials to regulate inflammation and vascularization, providing a potential therapeutic approach for PI repair.