Redox protection by bacterial glutathione peroxidase drives virulence in <i>Pseudomonas aeruginosa</i>
BACKGROUND: relies on antioxidant enzymes to withstand host-derived oxidative stress during infection. Here, we investigated the role of bacterial glutathione peroxidase (GPx) in survival and virulence of the PA14 strain under inflammatory conditions associated with hyperuricemia. METHODS: strains to assess bacterial burden, inflammation, oxidative damage, and survival. RESULTS: resistance to oxidative killing and promoting virulence. CONCLUSION: .
Authors
- Thiago Macêdo Lopes Correia (ORCID: https://orcid.org/0000-0003-1654-614X)
- Talita Costa dos Santos
- Railmara Pereira da Silva (ORCID: https://orcid.org/0000-0002-2831-4955)
- Robson Amaro Augusto da Silva (ORCID: https://orcid.org/0000-0003-1361-1591)
- Raphael Ferreira Queiroz (ORCID: https://orcid.org/0000-0002-7757-4286)
- Igor Pereira Ribeiro Muniz (ORCID: https://orcid.org/0000-0003-1842-6432)
- Álbert S. Peixoto (ORCID: https://orcid.org/0000-0002-7234-7252)
- Leonardo Silva Rocha (ORCID: https://orcid.org/0000-0002-9260-8421)
- Júlia de Oliveira Borges
- Regiane Yatsuda (ORCID: https://orcid.org/0000-0002-5018-9978)
- J Silva Cordeiro
- Amélia Cristina Mendes de Magalhães (ORCID: https://orcid.org/0000-0002-5335-4844)
- Flávia Carla Meotti (ORCID: https://orcid.org/0000-0002-7217-3352)
Institutions
- Universidade Federal da Bahia (BR)
- Universidade de São Paulo (BR)
- Southwest Bahia State University (BR)
Publication Details
- Journal
- Redox Report
- Published
- 2026-05-22
- DOI
- https://doi.org/10.1080/13510002.2026.2676357
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado da Bahia
- Universidade Estadual do Sudoeste da Bahia