Establishment of PDX/PDXO models to evaluate the antitumor efficacy and mechanism of Abemaciclib in gastric-type cervical cancer.
OBJECTIVE: experiments. METHODS: using PDX models. Mechanistic insights were investigated via network pharmacology and western blotting (WB). RESULTS: experiments demonstrated that abemaciclib significantly inhibited tumor growth in PDX-bearing mice. CONCLUSION: settings, highlighting its potential clinical application.
Authors
- Desheng Cai (ORCID: https://orcid.org/0000-0003-2246-1361)
- 何远桥
- Quan He (ORCID: https://orcid.org/0009-0009-2758-5575)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Yanping Zhang
- Xinxiu Lin
- Jiaqi Mei
- Limin Tao
- Chunhua Yin
- Junhui Wan
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Buchang Pharma (China) (CN)
- Jiang Xi Institute for Drug Control (CN)
- Jiangxi Agricultural University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-05-22
- DOI
- https://doi.org/10.14670/hh-25-095
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00