Exploring the Clinical Pharmacokinetics and Pharmacodynamics of Third-Generation Cephalosporin, a Cefotaxime: A Systematic Review
) of about 5.6% was observed when cefotaxime is co-administered with tazobactam. Therefore, cefotaxime depicts time-dependent killing above the minimum inhibitory concentration (MIC < 2 ug/ml), this property makes it suitable for managing infections caused by susceptible pathogens.4. This review compiles all the relevant PK and PD parameters of cefotaxime in healthy subjects. These data may assist health practitioners in adjusting the cefotaxime dose among renal failure patients to avoid toxicity.
Authors
- Hamid Saeed (ORCID: https://orcid.org/0000-0002-1400-4825)
- Muhammad Fawad Rasool (ORCID: https://orcid.org/0000-0002-8607-8583)
- F K Alqahtani
- Ammara Zamir
- Muhammad Zubaır (ORCID: https://orcid.org/0000-0003-4534-0968)
- Tahir Saleem
Institutions
- Bahauddin Zakariya University (PK)
- Allama Iqbal Open University (PK)
- Allama Iqbal Medical College (PK)
- King Saud University (SA)
Publication Details
- Journal
- Xenobiotica
- Published
- 2026-05-22
- DOI
- https://doi.org/10.1080/00498254.2026.2677148
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00