French NOMADMUS Cohort Overview
OBJECTIVES: Aquaporin 4-immunoglobulin G-seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are rare conditions with evolving diagnostic and therapeutic approaches. Our study aims to describe these evolutions in France, using data from the NOMADMUS cohort. METHODS: We retrospectively analyzed clinical, imaging, and therapeutic data collected across 98 French centers as of June 8, 2024. Patients were classified based on serologic status into AQP4+NMOSD or MOGAD. RESULTS: < 0.001, 0.21-0.68). Risk to reach EDSS 3 or 6 was lower in patients with MOGAD compared with AQP4+NMOSD patients. DISCUSSION: This nationwide registry revealed a reduction of the time to diagnosis, a decreased disease activity over time, and an evolution in the therapeutic strategies these past 15 years. This collaborative effort provides valuable insights into current knowledge about clinical practice and treatment patterns in real-world settings.
Authors
- Romain Deschamps (ORCID: https://orcid.org/0000-0001-6291-8771)
- Xavier Ayrignac (ORCID: https://orcid.org/0000-0003-3834-2981)
- Jonathan Ciron (ORCID: https://orcid.org/0000-0002-3386-6308)
- François Cotton (ORCID: https://orcid.org/0000-0003-0046-2478)
- Julie Pique
- Aurélie Ruet (ORCID: https://orcid.org/0000-0002-0020-8739)
- Romain Casey (ORCID: https://orcid.org/0000-0002-5918-9261)
- Lakhdar Benyahya (ORCID: https://orcid.org/0009-0005-0046-9487)
- B Stankoff
- Éric Thouvenot (ORCID: https://orcid.org/0000-0001-8671-7747)
- Nicolas Collongues (ORCID: https://orcid.org/0000-0002-3683-5582)
- Laure Michel (ORCID: https://orcid.org/0000-0002-8119-7794)
- C Papeix
- David Axel Laplaud (ORCID: https://orcid.org/0000-0001-6113-6938)
- Kumaran Deiva (ORCID: https://orcid.org/0000-0002-8409-2365)
- Françoise Durand-Dubief (ORCID: https://orcid.org/0000-0002-2860-1700)
- Thomas Roux (ORCID: https://orcid.org/0000-0002-6969-9943)
- Sandra Vukusic (ORCID: https://orcid.org/0000-0001-7337-7122)
- Valerie Touitou (ORCID: https://orcid.org/0000-0002-0103-2923)
- Helene Zephir (ORCID: https://orcid.org/0000-0003-4029-2012)
- Mikael Cohen (ORCID: https://orcid.org/0000-0002-3985-1297)
- Bertrand Audoin (ORCID: https://orcid.org/0000-0002-9860-7657)
- Romain Marignier (ORCID: https://orcid.org/0000-0002-5967-2800)
- Bertrand Bourre (ORCID: https://orcid.org/0000-0002-2459-2480)
- as the NOMADMUS Study Group
- François-Xavier Lejeune
- Elisabeth Maillart (ORCID: https://orcid.org/0000-0001-7699-0328)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Multiple Sclerosis Foundation (US)
- Centre Hospitalier Universitaire de Nice (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Référence des Maladies Autoinflammatoires et des Amyloses (FR)
- Hospices Civils de Lyon (FR)
- Observatoire Français de la Sclérose en Plaques (FR)
- Hôpital Pellegrin (FR)
- CIC Rennes (FR)
- Pitié-Salpêtrière Hospital (FR)
- Neurocentre Magendie (FR)
- Fondation de Rothschild (FR)
- Hôpital Pasteur (FR)
- Institut du Cerveau (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Hôpital de la Timone (FR)
- Bicêtre Hospital (FR)
- Hôpital Civil, Strasbourg (FR)
- Université de Nîmes (FR)
Publication Details
- Journal
- Neurology
- Published
- 2026-05-22
- DOI
- https://doi.org/10.1212/wnl.0000000000218073
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 0.00